Федеральное государственное бюджетное учреждение «Федеральный научно-клинический центр физико-химической медицины имени академика Ю.М. Лопухина Федерального медико-биологического агентства»

доктор химических наук, специальность 03.01.03 —
молекулярная биология, Федеральное государственное бюджетное учреждение
«Федеральный научно-клинический центр физико-химической медицины имени академика
Ю.М. Лопухина Федерального медико-биологического агентства», г. Москва, зав.
лабораторией структуры и функций биополимеров. Список основных публикаций по теме
диссертации за последние 5 лет:
1. Zaitseva, S. O., Baleeva, N. S., Zatsepin, T. S., Myasnyanko, I. N., Turaev, A. V.,
Pozmogova, G. E., Khrulev, A. A., Varizhuk, A. M., Baranov, M. S., Aralov, A. V. Short Duplex
Module Coupled to G-Quadruplexes Increases Fluorescence of Synthetic GFP Chromophore
Analogues // Sensors (Basel), 2020. Vol. 20, № 3. P. 915.
2. Subach, O. M., Sotskov, V. P., Plusnin, V. V., Gruzdeva, A. M., Barykina, N. V.,
Ivashkina, O. I., Anokhin, K. V., Nikolaeva, A. Y., Korzhenevskiy, D. A., Vlaskina, A. V.,
Lazarenko, V. A., Boyko, K. M., Rakitina, T. V., Varizhuk, A. M., Pozmogova, G. E., Podgorny,
O. V., Piatkevich, K. D., Boyden, E. S., Subach, F. V. Novel Genetically Encoded Bright Positive
Calcium Indicator NCaMP7 Based on the mNeonGreen Fluorescent Protein // Int. J. Mol. Sci.,
2020. Vol. 21, № 5. P. 1644.
3. Tsvetkov, V. B., Varizhuk, A. M., Lizunova, S. A., Nikolenko, T. A., Ivanov, I. A.,
Severov, V. V., Belyaev, E. S., Shitikov, E. A., Pozmogova, G. E., Aralov, A. V. Phenoxazinebased scaffold for designing G4-interacting agents // Org. Biomol. Chem., 2020. Vol. 18, № 31.
P. 6147–6154.
4. Pavlova, I. I., Tsvetkov, V. B., Isaakova, E. A., Severov, V. V., Khomyakova, E. A., Lacis,
I. A., Lazarev, V. N., Lagarkova, M. A., Pozmogova, G. E., Varizhuk, A. M. Transcriptionfacilitating histone chaperons interact with genomic and synthetic G4 structures // Int. J. Biol.
Macromol., 2020. Vol. 160. P. 1144–1157.
5. Turaev, A. V., Isaakova, E. A., Severov, V. V., Bogomazova, A. N., Zatsepin, T. S.,
Sardushkin, M. V., Aralov, A. V., Lagarkova, M. A., Pozmogova, G. E., Varizhuk, A. M.
Genomic DNA i-motifs as fast sensors responsive to near-physiological pH microchanges //
Biosens. Bioelectron., 2021. Vol. 175. P. 112864.
6. Tikhonova, P., Pavlova, I., Isaakova, E., Tsvetkov, V., Bogomazova, A., Vedekhina, T.,
Luzhin, A. V., Sultanov, R., Severov, V., Klimina, K., Kantidze, O. L., Pozmogova, G.,
Lagarkova, M., Varizhuk, A. DNA G-Quadruplexes Contribute to CTCF Recruitment // Int. J.
Mol. Sci., 2021. Vol. 22, № 13. P. 7090.
7. Shitikov, E., Bespiatykh, D., Malakhova, M., Bespyatykh, J., Bodoev, I., Vedekhina, T.,
Zaychikova, M., Veselovsky, V., Klimina, K., Ilina, E., Varizhuk, A. Genome-Wide
Transcriptional Response of Mycobacterium smegmatis MC2
155 to G-Quadruplex Ligands
BRACO-19 and TMPyP4 // Front. Microbiol., 2022. Vol. 13. P. 817024.
8. Aralov, A. V., Gubina, N., Cabrero, C., Tsvetkov, V. B., Turaev, A. V., Fedeles, B. I.,
Croy, R. G., Isaakova, E. A., Melnik, D., Dukova, S., Ryazantsev, D. Y., Khrulev, A. A.,
Varizhuk, A. M., González, C., Zatsepin, T. S., Essigmann, J. M. 7,8-Dihydro-8-oxo-1,N6-
ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T
transversions in Escherichia coli // Nucleic Acids Res., 2022. Vol. 50, № 6. P. 3056–3069.
9. Lizunova, S. A., Tsvetkov, V. B., Skvortsov, D. A., Kamzeeva, P. N., Ivanova, O. M.,
Vasilyeva, L. A., Chistov, A. A., Belyaev, E. S., Khrulev, A. A., Vedekhina, T. S., Bogomazova,
A. N., Lagarkova, M. A., Varizhuk, A. M., Aralov, A. V. Anticancer activity of G4-targeting
phenoxazine derivatives in vitro // Biochimie, 2022. Vol. 201. P. 43–54.
10. Subach, O. M., Vlaskina, A. V., Agapova, Y. K., Korzhenevskiy, D. A., Nikolaeva, A. Y.,
Varizhuk, A. M., Subach, M. F., Patrushev, M. V., Piatkevich, K. D., Boyko, K. M., Subach, F.
V. cNTnC and fYTnC2, Genetically Encoded Green Calcium Indicators Based on Troponin C
from Fast Animals // Int. J. Mol. Sci., 2022. Vol. 23, № 23. P. 14614.
11. Pavlova, I., Barinov, N., Novikov, R., Severov, V., Iudin, M., Vedekhina, T., Larin, A.,
Babenko, V., Aralov, A., Gnuchikh, E., Sardushkin, M., Klinov, D., Tsvetkov, V., Varizhuk, A.
Modeling G4s in chromatin context confirms partial nucleosome exclusion and reveals
nucleosome-disrupting effects of the least selective G4 ligands // Biochimie, 2023. Vol. 204. P. 8–
21.
12. Petrunina, N. A., Shtork, A. S., Lukina, M. M., Tsvetkov, V. B., Khodarovich, Y. M.,
Feofanov, A. V., Moysenovich, A. M., Maksimov, E. G., Shipunova, V. O., Zatsepin, T. S.,
Bogomazova, A. N., Shender, V. O., Aralov, A. V., Lagarkova, M. A., Varizhuk, A. M.
Ratiometric i-Motif-Based Sensor for Precise Long-Term Monitoring of pH Micro Alterations in
the Nucleoplasm and Interchromatin Granules // ACS Sens., 2023. Vol. 8, № 2. P. 619–629.
13. Bozin, T. N., Berdyshev, I. M., Chukhontseva, K. N., Karaseva, M. A., Konarev, P. V.,
Varizhuk, A. M., Lesovoy, D. M., Arseniev, A. S., Kostrov, S. V., Bocharov, E. V., Demidyuk,
I. V. NMR structure of emfourin, a novel protein metalloprotease inhibitor: Insights into the
mechanism of action // J. Biol. Chem., 2023. Vol. 299, № 4. P. 104585.
14. Bychenko, O. S., Khrulev, A. A., Svetlova, J. I., Tsvetkov, V. B., Kamzeeva, P. N.,
Skvortsova, Y. V., Tupertsev, B. S., Ivanov, I. A., Aseev, L. V., Khodarovich, Y. M., Belyaev, E.
S., Kozlovskaya, L. I., Zatsepin, T. S., Azhikina, T. L., Varizhuk, A. M., Aralov, A. V. Red light-
emitting short Mango-based system enables tracking a mycobacterial small noncoding RNA in
infected macrophages // Nucleic Acids Res., 2023. Vol. 51, № 6. P. 2586–2601.
15. Pavlova, I., Iudin, M., Surdina, A., Severov, V., Varizhuk, A. G-Quadruplexes in Nuclear
Biomolecular Condensates // Genes (Basel), 2023. Vol. 14, № 5. P. 1076.
16. Andreeva, D. V., Vedekhina, T. S., Gostev, A. S., Dezhenkova, L. G., Volodina, Y. L.,
Markova, A. A., Nguyen, M. T., Ivanova, O. M., Dolgusheva, V. А., Varizhuk, A. M.,
Tikhomirov, A. S., Shchekotikhin, A. E. Thiadiazole-, selenadiazole- and triazole-fused
anthraquinones as G-quadruplex targeting anticancer compounds // Eur. J. Med. Chem., 2024. Vol.
268. P. 116222.
17. Vedekhina, T., Svetlova, J., Pavlova, I., Barinov, N., Alieva, S., Malakhova, E., Rubtsov,
P., Shtork, A., Klinov, D., Varizhuk, A. Cross-Effects in Folding and Phase Transitions of hnRNP
A1 and C9Orf72 RNA G4 In Vitro // Molecules (Basel, Switzerland), 2024. Vol. 29, № 18. P.
4369.
18. Fisunov, G. Y., Tsvetkov, V. B., Tsoy, E. A., Evsyutina, D. V., Vedyaykin, A. D.,
Garanina, I. A., Semashko, T. A., Manuvera, V. A., Varizhuk, A. M., Kovalchuk, S. I., Zubov,
A. I., Barinov, N. A., Pobeguts, O. V., Govorun, V. M. WhiA transcription factor provides
feedback loop between translation and energy production in a genome-reduced bacterium // Front.
Microbiol., 2024. Vol. 15. P. 1504418.
19. Kamzeeva, P. N., Alferova, V. A., Korshun, V. A., Varizhuk, A. M., Aralov, A. V. 5′-
UTR G-Quadruplex-Mediated Translation Regulation in Eukaryotes: Current Understanding and
Methodological Challenges // Int. J. Mol. Sci., 2025. Vol. 26, № 3. P. 1187.
20. Pavlova, I. I., Ivanova, O. M., Iudin, M. S., Surdina, A. V., Barinov, N. A., Bogomiakova,
M. E., Oreshkov, S. D., Shenkarev, Z. O., Severov, V. V., Klinov, D. V., Shender, V. O.,
Bogomazova, A. N., Lagarkova, M. A., Varizhuk, A. M., Tsvetkov, V. B. G-quadruplexes as
potential traps for superenhancer marker BRD4: ligand-sensitive binding and co-separation
in vitro // Nucleic Acids Res., 2025. Vol. 53, № 14.
21. Svetlova, J. I., Bychenko, O. S., Slushko, G. K., Skvortsova, Y. V., Belyaev, E. S.,
Kamzeeva, P. N., Khodarovich, Y. M., Pakhomov, A. A., Azhikina, T. L., Varizhuk, A. M.,
Aralov, A. V. A genetically encoded Mango II-based system with increased brightness and
selectivity for imaging RNAs in live cells // Org. Biomol. Chem., 2025. Advance online
publication. https://doi.org/10.1039/d5ob01004g